Krebs und Telomere

Zusammenfassung

Krebszellen haben im Allgemeinen kürzere Telomere als normale Zellen. Im Gegensatz zu normalen Zellen haben sie jedoch durch Aktivierung der Telomerase oder anderer Mechanismen einen Weg gefunden, die Telomerlänge aufrechtzuerhalten und so den Zelltod zu umgehen. Neue Forschungsergebnisse zeigen, dass die Telomerbiologie diese Mechanismen stören oder beeinflussen kann und somit möglicherweise in Zukunft ein weiteres Mittel im Kampf gegen den Krebs darstellen wird.

Summary

In general, cancer cells have shorter telomeres than normal somatic cells. However, compared to normal cells, they use reactivation of telomerase or other mechanisms to maintain telomere length and in consequence to bypass cell death. New results indicate that telomere biology might be a good tool for the fight against cancer in the future by disturbing or influencing these mechanisms.

Schlüsselwörter

Telomere - Krebs - DNA-Reparatur

Keywords

telomer - cancer - DNA-repair

Literatur

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