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Synfacts 2008(4): 0343-0343  
DOI: 10.1055/s-2008-1042881
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Phomactin B2

Contributor(s): Philip Kocienski, Arndt W. Schmidt
J. Huang, C. Wu, W. D. Wulff*
Michigan State University, East Lansing, USA
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Publikationsdatum:
19. März 2008 (online)

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Significance

The bicyclo[9.3.1]tetradecane skeleton of phomactin B2, which is the common feature of all phomactins, is constructed in a single step by an intramolecular Dötz annulation of an appropriately substituted chromium carbene. Starting from geraniol, (±)-phomactin B2 was obtained after 26 steps.