PDF herunterladen
Synfacts 2008(4): 0374-0374  
DOI: 10.1055/s-2008-1042866
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rhodium-Catalyzed Enantioselective Direct Aldol Reaction

Contributor(s): Hisashi Yamamoto, Marina Naodovic
H. Inoue, M. Kikuchi, J.-I. Ito, H. Nishiyama*
Nagoya University, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
19. März 2008 (online)

    Lizenzen und Reprints

Significance

The rhodium-bis(oxazolinyl)phenyl complex is shown to effectively promote the direct aldol reaction yielding products in highly stereo­selective fashion. The authors suggest that ‘Phebox’-Rh catalyst incorporates both Lewis acidic and Brønstead basic sites which are responsible for activation of the carbonyl group and formation of the enolate moiety.