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Synfacts 2008(4): 0425-0425  
DOI: 10.1055/s-2008-1042831
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York

Biocatalytic Reduction of Aryl Imines

Contributor(s): Benjamin List, Frank Lay
T. Vaijayanthi, A. Chadha*
Indian Institute of Technology Madras, Chennai, India
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

The authors developed a one-pot biocatalytic method for the asymmetric reduction of aryl imines 1. Whole cells of Candida parapsilosis ATCC 7330 (2) generate the corresponding secondary amines 3 without the need for adding a cofactor in aqueous medium. Excellent enantiomeric ratios (er = 97.5:2.5 up to >99.5:0.5) and good yields (55-80%) are reported.