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Synfacts 2008(3): 0326-0326  
DOI: 10.1055/s-2008-1042672
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Superior Liquid-Uptake Resins for Polymer-Supported Synthesis (SLURPS)

Contributor(s): Yasuhiro Uozumi, Takao Osako
G. Cavalli, A. G. Shooter, D. A. Pears, D. A. Wellings, S. Gulzar, J. H. G. Steinke*
Imperial College London, Avecia Ltd., Manchester and Avecia Ltd., Runcorn, UK
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Publikationsdatum:
21. Februar 2008 (online)

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Significance

A series of novel polymer resins, SLURPS, exhibiting relatively uniform swelling properties for a wide range of solvents was prepared via cationic polymerization of vinyl ethers. The loading value of the functional group was readily controlled by changing the mixing ratio of the monomers 1 and 2. The functional group of resin 4 was converted stepwise into OH, Br, NH2. Solid-phase synthesis of a pentapeptide Leuenkephalin was performed on the SLURPS resins as solid supports to demonstrate their synthetic utility.