ABSTRACT
Fifty-two consecutive infants who received intravenous indomethacin, 0.2 mg/kg, were
reviewed to determine factors associated with the occurrence of oliguria. Serum creatinine
and concentration prior to indomethacin did not predict the occurrence of oliguria.
A mean urine output of less than 4.5 mL/kg/hr prior to the administration of indomethacin
was the only factor that we determined to be associated with a significant risk of
oliguria. Two infants developed symptomatic oliguria and both had a preindomethacin
urine output less than 1.5mL/kg/hr.
