Zusammenfassung
Krebsgentherapie ist vom Grundkonzept her ein vielversprechender neuer Ansatz zur
Behandlung von Malignomen, die einer konventionellen Tumortherapie gegenüber resistent
sind. Die verschiedenen Ansätze basieren auf den molekularen Unterschieden zwischen
normalen Zellen und Tumorzellen, welche für eine gezielte Behandlung genutzt werden.
In Bezug auf gynäkologische Malignome wurden in den vergangenen Jahren verschiedene
präklinische und klinische Behandlungsansätze entwickelt. Die Daten zeigen eine hohe
Therapiesicherheit für die verschiedenen Gentherapieansätze, die klinische Effizienz
ist jedoch bis heute unbefriedigend. Eine große Herausforderung liegt somit in der
Verbesserung der Effizienz und Spezifität der eingesetzten Gentransfervektoren. Diese
Arbeit legt den Schwerpunkt auf aktuelle und zukünftige Gentransferverfahren in der
Behandlung gynäkologischer Malignome.
Abstract
Gene therapy is a potentially useful approach for the treatment of malignancies refractory
to conventional therapies. Various preclinical and clinical strategies have explored
the feasibility of gene therapy for different diseases. Given the urgent need for
novel treatment modalities, much of the work to date has focused on gynaecologic malignancies,
in particular on ovarian cancer. Although the safety of many approaches has been demonstrated
in early phase clinical trials, the efficacy of the different gene therapy approaches
has been limited so far. Major challenges include improving gene transfer vectors
for enhanced and selective delivery and achieving effective spread of the vector in
advanced tumour masses and bulky disease. This review focuses on current and future
gene transfer applications for gynaecologic diseases.
Schlüsselwörter
Gentherapie - gynäkologische Tumoren - virale Vektoren
Key words
gene therapy - gynaecologic malignancies - viral vectors
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Daniel T. Rein
Universitätsfrauenklinik Düsseldorf
Moorenstraße 5
40225 Düsseldorf
Email: rein@med.uni-duesseldorf.de
