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Pneumologie 2008; 62(12): 718-729
DOI: 10.1055/s-2008-1038270
DOI: 10.1055/s-2008-1038270
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New YorkAktuelle und neue Medikamente in der Tabakentwöhnung
Current and Future Medical Drugs for Smoking CessationFurther Information
Publication History
Publication Date:
02 December 2008 (online)

Lerninhalte
Grundlagenwissen zur Epidemiologie und Auswirkungen von Tabakkonsum Grundlagenwissen zur neurobiologischen Wirkung des Rauchens Definition von Tabaksucht Differenzierte Beschreibung der Therapieformen der Tabakentwöhnung, Vergleich von pharmakologischen und verhaltenstherapeutischen Ansätzen
Literatur
- 1 World Health Organization .The facts about smoking and health. 2006
MissingFormLabel
- 2 Becker N, Wahrendorf J H. Krebsatlas der Bundesrepublik Deutschland 1981 – 1990. Heidelberg: Springer 1998
MissingFormLabel
- 3 Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. (GKID) .Krebs in Deutschland. Häufigkeiten und Trends. Saarbrücken: Krebsregister 2006
MissingFormLabel
- 4 Deutsches Krebsforschungszentrum (DKFZ) .Passivrauchende Kinder in Deutschland – Frühe Schädigungen für ein ganzes Leben. Heidelberg 2003
MissingFormLabel
- 5 US Department of Health and Human Services .The health benefits of smoking cessation: A report of the Surgeon General. Atlanta: US Department of Health and Human Services, Centers for Disease Control and
Prevention, Center for Chronic Disease Prevention and Health Promotion, Public Health
Service, Office on Smoking and Health 1990
MissingFormLabel
- 6
Balfour D J, Fagerstrom K O.
Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative
disorders.
Pharmacol Ther.
1996;
72
51-81
MissingFormLabel
- 7
Balfour D J, Benwell M E, Birrell C E. et al .
Sensitization of the mesoaccumbens dopamine response to nicotine.
Pharmacol Biochem Behav.
1998;
59
1021-1030
MissingFormLabel
- 8
Pomerleau O F.
Nicotine and the central nervous system: biobehavioral effects of cigarette smoking.
Am J Med.
1992;
93
2S-7S
MissingFormLabel
- 9
Epping-Jordan M P, Watkins S S, Koob G F. et al .
Dramatic decreases in brain reward function during nicotine withdrawal.
Nature.
1998;
393
76-79
MissingFormLabel
- 10
Picciotto M R, Zoli M, Rimondini R. et al .
Acetylcholine receptors containing the beta 2 subunit are involved in the reinforcing
properties of nicotine.
Nature.
1998;
391
173-177
MissingFormLabel
- 11
Furtado R.
Implicações anestésicas do tabagismo.
Rev Bras Anestesiol.
2002;
52
354-367
MissingFormLabel
- 12 Batra A. Tabakabhängigkeit. Biologische und psychosoziale Entstehungsbedingungen und Therapiemöglichkeiten. Darmstadt: Steinkopf 2000
MissingFormLabel
- 13
Marques A CPR. et al .
Consenso sobre o tratamento da dependência de nicotina.
Rev Bras Psiquiatr.
2001;
23
200-214
MissingFormLabel
- 14 US Department of Health and Human Services .The Health Consequences of Smoking: Nicotine Addiction: A Report of the Surgeon General. Rockville, Maryland 1988
MissingFormLabel
- 15 Dilling H, Monbour W, Schmidt M H. Internationale Klassifikation psychischer Störungen: ICD-10, Kapitel V (F). Göttingen: Huber 1991
MissingFormLabel
- 16 Saß H, Wittchen H U, Zaudig M. Diagnostisches und Statistisches Manual Psychischer Störungen DSM IV. Göttingen, Bern, Toronto, Seattle: Hogrefe 1996
MissingFormLabel
- 17
Batra A, Fagerström K O.
Neue Aspekte der Nikotinabhängigkeit und Raucherentwöhnung.
Sucht.
1997;
43
277-282
MissingFormLabel
- 18
Breslau N, Johnson E O, Hiripi E. et al .
Nicotine dependence in the United States: prevalence, trends, and smoking persistence.
Arch Gen Psychiatry.
2001;
58
810-816
MissingFormLabel
- 19 World Health Organization .Tobacco or health: a global status report. Geneva: World Health Organization 1997
MissingFormLabel
- 20
Fagerstrom K O, Schneider N G.
Measuring nicotine dependence: a review of the Fagerstrom Tolerance Questionnaire.
J Behav Med.
1989;
12
159-182
MissingFormLabel
- 21
Lagrue G, Lafnoune N, Cormier S. et al .
Urinary cotinine-creatinine ratio as a marker of nicotine intake: a guide for the
nicotine replacement therapy during smoking cessation. Congrès annuel ERS, Florence
1993.
Eur Respir J.
1993;
6
MissingFormLabel
- 22 Fiore M C, Bailey W C, Cohen S J. Treating tobacco use and dependence. Clinical practice guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service 2000
MissingFormLabel
- 23
Haustein K O.
Pharmacotherapy of nicotine dependence.
Int J Clin Pharmacol Ther.
2000;
38
273-290
MissingFormLabel
- 24
Henningfield J E.
Nicotine medications for smoking cessation.
N Engl J Med.
1995;
333
1196-1203
MissingFormLabel
- 25
Mühling S, Nowak D.
9 Thesen zur Raucherentwöhnung.
Suchtmed.
2004;
6
MissingFormLabel
- 26
Nowak D, Hoch E.
Raucherentwöhnung – Pharmakologie, Effizienz und Hemmnisse.
Bay Int.
2005;
25
118-126
MissingFormLabel
- 27
Schön S, Nowak D.
Medikamentöse Verfahren zur Raucherentwöhnung.
Suchtmed.
2002;
4
189-199
MissingFormLabel
- 28
Silagy C, Lancaster T, Stead L. et al .
Nicotine replacement therapy for smoking cessation.
Cochrane Database Syst Rev.
2004;
CD000146
MissingFormLabel
- 29
Henningfield J E, Fant R V, Buchhalter A R. et al .
Pharmacotherapy for nicotine dependence.
CA Cancer J Clin.
2005;
55
281-299; quiz 322 – 283, 325
MissingFormLabel
- 30
Mitrouska I, Bouloukaki I, Siafakas N M.
Pharmacological approaches to smoking cessation.
Pulm Pharmacol Ther.
2007;
20
220-232
MissingFormLabel
- 31
Wu P, Wilson K, Dimoulas P. et al .
Effectiveness of smoking cessation therapies: a systematic review and meta-analysis.
BMC Public Health.
2006;
6
300
MissingFormLabel
- 32
Fiore M C.
Treating tobacco use and dependence: an introduction to the US Public Health Service
Clinical Practice Guideline.
Respir Care.
2000;
45
1196-1199
MissingFormLabel
- 33
Hjalmarson A, Franzon M, Westin A. et al .
Effect of nicotine nasal spray on smoking cessation. A randomized, placebo-controlled,
double-blind study.
Arch Intern Med.
1994;
154
2567-2572
MissingFormLabel
- 34
Sutherland G, Stapleton J A, Russell M A. et al .
Randomised controlled trial of nasal nicotine spray in smoking cessation.
Lancet.
1992;
340
324-329
MissingFormLabel
- 35
Sutherland G, Russell M A, Stapleton J. et al .
Nasal nicotine spray: a rapid nicotine delivery system.
Psychopharmacology (Berl).
1992;
108
512-518
MissingFormLabel
- 36
Choi J H, Dresler C M, Norton M R. et al .
Pharmacokinetics of a nicotine polacrilex lozenge.
Nicotine Tob Res.
2003;
5
635-644
MissingFormLabel
- 37
Shiffman S, Dresler C M, Hajek P. et al .
Efficacy of a nicotine lozenge for smoking cessation.
Arch Intern Med.
2002;
162
1267-1276
MissingFormLabel
- 38
Blondal T, Gudmundsson L J, Olafsdottir I. et al .
Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with
six year follow up.
Bmj.
1999;
318
285-288
MissingFormLabel
- 39
Bohadana A, Nilsson F, Rasmussen T. et al .
Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation:
a randomized, double-blind, placebo-controlled trial.
Arch Intern Med.
2000;
160
3128-3134
MissingFormLabel
- 40
Kornitzer M, Boutsen M, Dramaix M. et al .
Combined use of nicotine patch and gum in smoking cessation: a placebo-controlled
clinical trial.
Prev Med.
1995;
24
41-47
MissingFormLabel
- 41
Benowitz N L.
Clinical pharmacology of nicotine: implications for understanding, preventing, and
treating tobacco addiction.
Clin Pharmacol Ther.
2008;
83
531-541
MissingFormLabel
- 42
Hays J T, Ebbert J O.
Bupropion for the treatment of tobacco dependence: guidelines for balancing risks
and benefits.
CNS Drugs.
2003;
17
71-83
MissingFormLabel
- 43
Slemmer J E, Martin B R, Damaj M I.
Bupropion is a nicotinic antagonist.
J Pharmacol Exp Ther.
2000;
295
321-327
MissingFormLabel
- 44
Hurt R D, Sachs D P, Glover E D. et al .
A comparison of sustained-release bupropion and placebo for smoking cessation.
N Engl J Med.
1997;
337
1195-1202
MissingFormLabel
- 45
Lee A M, Jepson C, Hoffmann E. et al .
CYP2B6 genotype alters abstinence rates in a bupropion smoking cessation trial.
Biol Psychiatry.
2007;
62
635-641
MissingFormLabel
- 46
Jorenby D E, Leischow S J, Nides M A. et al .
A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking
cessation.
N Engl J Med.
1999;
340
685-691
MissingFormLabel
- 47
Hughes J R, Stead L F, Lancaster T.
Antidepressants for smoking cessation.
Cochrane Database Syst Rev.
2007;
CD000031
MissingFormLabel
- 48
Roddy E.
Bupropion and other non-nicotine pharmacotherapies.
Bmj.
2004;
328
509-511
MissingFormLabel
- 49
George T P, O'Malley S S.
Current pharmacological treatments for nicotine dependence.
Trends Pharmacol Sci.
2004;
25
42-48
MissingFormLabel
- 50
Jorenby D.
Clinical efficacy of bupropion in the management of smoking cessation.
Drugs.
2002;
62 Suppl 2
5-35
MissingFormLabel
- 51
Aubin H J.
Tolerability and safety of sustained-release bupropion in the management of smoking
cessation.
Drugs.
2002;
62 Suppl 2
45-52
MissingFormLabel
- 52
Settle Jr E C.
Bupropion sustained release: side effect profile.
J Clin Psychiatry.
1998;
59 Suppl 4
32-36
MissingFormLabel
- 53
da Costa C L, Younes R N, Lourenco M T.
Stopping smoking: a prospective, randomized, double-blind study comparing nortriptyline
to placebo.
Chest.
2002;
122
403-408
MissingFormLabel
- 54
Hall S M, Reus V I, Munoz R F. et al .
Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking.
Arch Gen Psychiatry.
1998;
55
683-690
MissingFormLabel
- 55
Ferry L H.
Non-nicotine pharmacotherapy for smoking cessation.
Prim Care.
1999;
26
653-669
MissingFormLabel
- 56
Abbot N C, Stead L F, White A R. et al .
Hypnotherapy for smoking cessation.
Cochrane Database Syst Rev.
2000;
CD001008
MissingFormLabel
- 57
Prochazka A V, Kick S, Steinbrunn C. et al .
A randomized trial of nortriptyline combined with transdermal nicotine for smoking
cessation.
Arch Intern Med.
2004;
164
2229-2233
MissingFormLabel
- 58
Gourlay S G, Stead L F, Benowitz N L.
Clonidine for smoking cessation.
Cochrane Database Syst Rev.
2004;
CD000058
MissingFormLabel
- 59
Jorenby D E, Hays J T, Rigotti N A. et al .
Efficacy of varenicline, an alpha-4-beta-2-nicotinic acetylcholine receptor partial
agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized
controlled trial.
Jama.
2006;
296
56-63
MissingFormLabel
- 60
Cohen C, Perrault G, Voltz C. et al .
SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational
and dopamine-releasing effects of nicotine in rats.
Behav Pharmacol.
2002;
13
451-463
MissingFormLabel
- 61 Anthenelli R, Despres J. Effects of rimonabant in the reduction of major car-diovascular risk factors. Results
from the STRATUS-US trial (smoking cessation in smokers motivated to quit). Presented
at Am. College Cardiol. 53rd Annu. Sci. Session. New Orleans, LA: Rapid News Summaries 2004
MissingFormLabel
- 62 Anthenelli R. Rimonabantin smoking abstinence: the STRATUS-programm. in Proc. 11 Annu. Meet. Soc.
Res. Nicotine Tobacco. Prague, Czech 2005
MissingFormLabel
- 63 EMEA .Questions and answers on the safety of Acomplia (Rimonabant).
http://www.emea.europa.eu/humandocs/PDFs/EPAR/acomplia/H-666-qa.pdf. London: European Medicines Agency 2007
MissingFormLabel
- 64
Cerny T.
Anti-nicotine vaccination: where are we?.
Recent Results Cancer Res.
2005;
166
167-175
MissingFormLabel
- 65
Hieda Y, Keyler D E, Ennifar S. et al .
Vaccination against nicotine during continued nicotine administration in rats: immunogenicity
of the vaccine and effects on nicotine distribution to brain.
Int J Immunopharmacol.
2000;
22
809-819
MissingFormLabel
- 66
Pentel P R, Malin D H, Ennifar S. et al .
A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates
its behavioral and cardiovascular effects in rats.
Pharmacol Biochem Behav.
2000;
65
191-198
MissingFormLabel
- 67
Le Houezec J.
Why a nicotine vaccine?.
Clin Pharmacol Ther.
2005;
78
453-455
MissingFormLabel
- 68
LeSage M G, Keyler D E, Pentel P R.
Current status of immunologic approaches to treating tobacco dependence: vaccines
and nicotine-specific antibodies.
Aaps J.
2006;
8
E65-75
MissingFormLabel
- 69
Lindblom N, de Villiers S H, Kalayanov G. et al .
Active immunization against nicotine prevents reinstatement of nicotine-seeking behavior
in rats.
Respiration.
2002;
69
254-260
MissingFormLabel
- 70 Cytos Biotechnology .Impfstoff zur Behandlung der Nikotinsucht fördert anhaltende Abstinenz während 12
Monaten bei Probanden mit hohen Antikörperwerten.
http://www.cytos.com/doc/Cytos_Press_D_051 117.pdf. Schlieren: Cytos Biotechnology AG 2005
MissingFormLabel
- 71
Hatsukami D K, Rennard S, Jorenby D. et al .
Safety and immunogenicity of a nicotine conjugate vaccine in current smokers.
Clin Pharmacol Ther.
2005;
78
456-467
MissingFormLabel
- 72
Maurer P, Jennings G T, Willers J. et al .
A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety
and immunogenicity.
Eur J Immunol.
2005;
35
2031-2040
MissingFormLabel
- 73
White A R, Rampes H, Campbell J L.
Acupuncture and related interventions for smoking cessation.
Cochrane Database Syst Rev.
2006;
CD000009
MissingFormLabel
- 74
Balbani A, Montovani J.
Methods for smoking cessation and treatment of nicotine dependence.
Rev Bras Otorrinolaringol.
2005;
71
820-827
MissingFormLabel
- 75
Villano L M, White A R.
Alternative therapies for tobacco dependence.
Med Clin North Am.
2004;
88
1607-1621
MissingFormLabel
- 76
Stead L F, Lancaster T.
Group behaviour therapy programmes for smoking cessation.
Cochrane Database Syst Rev.
2002;
CD001007
MissingFormLabel
- 77
West R, McNeill A, Raw M.
Smoking cessation guidelines for health professionals: an update. Health Education
Authority.
Thorax.
2000;
55
987-999
MissingFormLabel
- 78 Deutsche Hauptstelle gegen die Suchtgefahren e. V. (DHS) .Frau SUCHT Gesundheit. Die Luft anhalten oder: Warum rauchen Frauen?.
http://www.dhs.de/makeit/cms/cms_upload/dhs/die_luft_anhalten_low.pdf
Hamm 2000
MissingFormLabel
Dipl. Psych. Bianca Kusma
Institut für Arbeitsmedizin
Thielallee 69 – 73
14159 Berlin
Email: bianca.kusma@charite.de