Anti-Infective and Cytotoxic Compounds Present in Blepharodon nitidum

Abstract

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en-3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

Key words

Blepharodon nitidum - Asclepiadaceae - hydroperoxycycloartanes - antileishmania - anti-infective - cytotoxic

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