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Am J Perinatol 1987; 4(3): 262-265
DOI: 10.1055/s-2007-999787
ORIGINAL ARTICLE

© 1987 by Thieme Medical Publishers, Inc.

An Evaluation of Gentamicin Dosing According to Renal Function in Neonates with Suspected Sepsis

Leanne D. Reimche1 , Michael E. Rooney1 , K. Wayne Hindmarsh1 , Dennis K.J. Gorecki1 , A. J. Remillard1 , Koravangattu Sankaran2
  • 1College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan
  • 2Perinatal Research Laboratory Neonatal Services, and Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Aminoglycoside antibiotics are frequently used for the treatment of suspected and confirmed sepsis in the newborn patient. In an attempt to evaluate gentamicin dosing based on serum creatinine concentrations, two groups of neonates were studied (infants < 34 weeks n = 8 and > 34 weeks n = 14). The dosing interval was adjusted per protocol depending on the serum creatinine concentrations. Analysis of the results indicate reasonable therapeutic serum gentamicin trough and peak concentrations in most infants.