Review of Fetal Cardiovascular and Metabolic Responses to Diabetic Insults in the Pregnant EWE

Kenneth E. Clark; Menachem Miodovnik; Carmela A. Skillman; Francis Mimouni

doi:10.1055/s-2007-999716

American Journal of Perinatology, Table of Contents

Am J Perinatol 1988; 5(4): 312-318
DOI: 10.1055/s-2007-999716

ORIGINAL ARTICLE

Review of Fetal Cardiovascular and Metabolic Responses to Diabetic Insults in the Pregnant EWE

Kenneth E. Clark, Menachem Miodovnik, Carmela A. Skillman, Francis Mimouni

The A.E. Seeds Perinatal Research Center and the Perinatal Research Institute, the Departments of Obstetrics and Gynecology and Pediatric Neonatology, University of Cincinnati College of Medicine, Cincinnati, Ohio

Abstract

ABSTRACT

Studies with pregnant sheep are reviewed, which were designed to investigate whether short term episodes of maternal hyperglycemia or hyperketonemia were detrimental to the fetus, whether ketones can cross the ovine placenta, and whether the combination of maternal hyperglycemia and hyperketonemia would contribute to an increased risk of fetal morbidity. It is concluded that acute increases in maternal ketones appear to be more detrimental to the fetus than acute increases in maternal glucose, as assessed by fetal cardiovascular, metabolic, and blood gas changes.

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