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Am J Perinatol 1998; 15(12): 689-694
DOI: 10.1055/s-2007-999303
ORIGINAL ARTICLE

© 1999 by Thieme Medical Publishers, Inc.

Congenital Erythroleukemia in a Neonate with Severe Hypoxic Ischemic Encephalopathy

Anastasia Hadjiyannakis1 , W. Allen Fletcher2 , David P. Lebrun2 , Richard C. van Wylick1 , Kimberly E. Dow1
  • 1Department of Pediatrics, Queen's University, Kingston, Ontario, Canada
  • 2Department of Pathology, Queen's University, Kingston, Ontario, Canada
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

We report a case of a neonate who presented with hypoxic ischemic encephalopathy, persistent hypoglycemia and hypotension, intractable metabolic acidosis, renal failure and a coagulopathy but who, at autopsy, was found to have massive infiltration of nonhematopoietic tissues with blasts. The diagnosis of congenital erythroleukemia was confirmed by the detection of glycophorin A, a major erythrocyte membrane protein, on the surface of the blasts. The clinical presentation and course of the case described here have not previously been reported for this extremely rare condition.

Keywords

Congenital leukemia - erythroleukemia - glycophorin A - hypoxic ischemic encephalopathy