Enhancement of Neonatal Neutrophil Motility (Chemotaxis) with Adult Fresh Frozen Plasma

Leonard Eisenfeld; Peter J. Krause; Victor C. Herson; Charlotte Block; James B. Schick; Eufronio Maderazo

doi:10.1055/s-2007-994659

American Journal of Perinatology, Table of Contents

Am J Perinatol 1992; 9(1): 5-8
DOI: 10.1055/s-2007-994659

ORIGINAL ARTICLE

Enhancement of Neonatal Neutrophil Motility (Chemotaxis) with Adult Fresh Frozen Plasma

Leonard Eisenfeld, Peter J. Krause, Victor C. Herson, Charlotte Block, James B. Schick, Eufronio Maderazo

Department of Pediatrics and Medicine, Hartford Hospital, and St. Francis Hospital, University of Connecticut School of Medicine, Hartford, Connecticut

Abstract

ABSTRACT

We examined the effect of adult fresh frozen plasma (FFP) on neonatal neutrophil (PMN) motility (chemotaxis) using a micropore filter assay. Adult FFP was transfused into 13 neonates receiving FFP transfusion for suspected life-threatening sepsis. Blood was obtained from neonates before and after FFP transfusion for assessment of PMN chemotaxis. An increase in PMN chemotaxis was noted in 12 of the 13 neonates following FFP transfusion, with a mean percentage increase of 12 ± 3% (p < 0.01). PMN chemotaxis increased 13 ± 2% (p < 0.01) in four bacteremic infants and 11 ± 5% (p = 0.06) in nine infants without bacteremia. Adult FFP transfusion may enhance impaired neonatal PMN motility and improve outcome from infection in newborn infants.

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