Neurofibromatosis (NF) is a common genetic disease that affects multiple organ systems.
We studied eight women with NF and the outcome of their 14 pregnancies. One patient
and her fetus died of a massive intracranial hemorrhage as a result of ruptured glioblastoma
of the basal ganglia. The incidence of live birth and preterm labor were 50% and 28.6%,
respectively. One of 14 pregnancies (7.1%) resulted in spontaneous abortion. There
was also one growth-retarded fetus in this series (7.1%). Perinatal implications of
this disease and management guidelines are discussed.
Neurofibromatosis - genetic disease - pregnancy
