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Am J Perinatol 1998; 15(6): 399-402
DOI: 10.1055/s-2007-993965
ORIGINAL ARTICLE

© 1998 by Thieme Medical Publishers, Inc.

Neonatal Middle Cerebral Artery Infarction: Association with Elevated Maternal Anticardiolipin Antibodies

Leyla F. Akanli1 , Sunil S. Trasi2 , Kalpna Thuraisamy3 , Marcia P. Bergtraum4 , Annabella Thantu5 , Rita F. Fischer6 , Nicole Cohen-Addad6
  • 1Department of Pediatrics, Division of Pulmonology, Westchester County Medical Center, Valhalla, New York, Medical College, Valhalla, New York
  • 2Department of Radiology, Section of Neuroradiology, Saint Vincents Hospital and Medical Center, New York, NY, New York Medical College, Valhalla, New York
  • 3Department of Medicine and Pediatrics, Saint Vincents Hospital and Medical Center, New York, NY
  • 4Department of Pediatrics, Schneider's Children's Hospital, Long Island, New York
  • 5Department of Pediatrics, Kenmore Mercy Hospital, Kenmore, New York, State University of New York, Buffalo, New York
  • 6Department of Pediatrics, Division of Neonatology, Saint Vincents Hospital and Medical Center, New York, NY, New York Medical College, Valhalla, New York
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

A full-term neonate was born to a 41-year-old woman via elective primary cesarean section for frank breech presentation after a 41-week pregnancy. Starting at 6 hr of age the infant presented with multiple episodes of apnea and cyanosis, in association with moderate hypotonia, subsequently requiring assisted ventilatory support for 2 days. Computerized axial tomography of the brain revealed infarction in the distribution of the left middle cerebral artery. Magnetic resonance imaging of the brain showed a left middle cerebral artery territory infarct and also a small right posterior-temporal in-farct. Magnetic resonance angiography of the head and neck was normal, however, inferring that the vascular infarction was peripheral in location. Maternal anticardiolipin antibodies were elevated. This is only the fifth reported case of cerebral infarction in a newborn in association with elevated maternal anticardiolipin antibodies.

Keywords

Newborn - cerebral infarct - anticardiolipin antibodies

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