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Synfacts 2008(2): 0141-0141  
DOI: 10.1055/s-2007-992459
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

2-Benzofuran-2-acetamides via Sequential Pd(0)-Pd(II) Catalysis

Contributor(s): Victor Snieckus, Johnathan Board
B. Gabriele*, R. Mancuso, G. Salerno, M. Costa
Università della Calabria, Arcavacata di Rende, Italy
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Publication History

Publication Date:
23 January 2008 (online)

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Significance

Reported is the one-pot synthesis of highly substituted benzofuran-2-ylacetamides from the reaction of 1-(2-allyloxyaryl)-2-yn-1-ols under sequential Pd(0)-Pd(II)-homobimetallic catalysis; there are two reactions performed in sequence by two different complexes of the same metal in different oxidation states. The proposed mechanism is reasonable and is supported by the detection of intermediates of type A in the reaction mixture.