Abstract
Introduction: The goal of this study is to assess, prospectively, the relative contribution of
baseline variables to long-term medication adherence in patients with a first episode
of schizophrenia.
Methods: Consecutively admitted patients suffering from a first episode of schizophrenia or
related disorders were investigated. Subjective experience, attitudes towards treatment,
insight, interaction with members of staff, involuntary admission, substance abuse,
and severity of psychopathology were independently assessed at first admission and
related to medication adherence during five year follow up.
Results: Standard multiple regression analysis revealed that hostility and uncooperativeness
(p=0.007) and involuntary admission (p=0.02) were associated with the level of adherence
during 5 year follow-up after admission.
Discussion: In first episode schizophrenia and related disorders, the initial interaction with
staff and involuntary admission partly predicts long-term adherence to antipsychotic
medication. Ameliorating these initial interactions might have long-term consequences
on medication adherence. Involuntary admitted patients need intensive outpatient care.
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Correspondence
L. de HaanMD,PhD
Postbus 75867
1070 AW Amsterdam
The Netherlands
Telefon: +31/020/891 37 09
Fax: +31/020/891 37 02
eMail: L.deHaan@amc.uva.nl
