Semin Liver Dis 2007; 27(4): 427-431
DOI: 10.1055/s-2007-991518
DIAGNOSTIC PROBLEMS IN HEPATOLOGY

© Thieme Medical Publishers

Hepatocellular Carcinoma and Congenital Absence of the Portal Vein in a Child Receiving Growth Hormone Therapy for Turner Syndrome

Raffaella A. Morotti1 , 3 , Mary Killackey2 , Benjamin L. Shneider2 , 3 , Anthony Repucci4 , Sukru Emre2 , 3 , Swan N. Thung1
  • 1Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York
  • 2Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, New York, New York
  • 3Department of Pediatrics, Mount Sinai School of Medicine, New York, New York
  • 4Connecticut Children's Medical Center, Hartford, Connecticut
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Publication History

Publication Date:
02 November 2007 (online)

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ABSTRACT

Turner syndrome patients are reported to have no increase in the relative risk of cancer, and hepatocellular carcinoma in particular has never been reported in this syndrome. However, Turner syndrome patients are known to have an increased prevalence of liver lesions, some of which, like focal nodular hyperplasia, are related to vascular anomalies. We report the case of a young patient with Turner syndrome, treated with recombinant human growth hormone, who was found to have absence of the portal vein, focal nodular hyperplasia, and hepatic adenoma and who developed a large hepatocellular carcinoma requiring liver transplant.

REFERENCES

Raffaella A MorottiM.D. 

Department of Pathology, Box 1194, Mount Sinai School of Medicine

One Gustave L. Levy Place, New York, NY 10029

Email: raffaella.morotti@mountsinai.org