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Synfacts 2008(1): 0014-0014  
DOI: 10.1055/s-2007-991491
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Drupicine

Contributor(s): Philip Kocienski
Q. Li, E. M. Ferreira, B. M. Stoltz*
California Institute of Technology, Pasadena, USA
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

The Stoltz group accomplished the first asymmetric synthesis of drupicine, the core structure of the antileukemic Cephalotaxus alkaloid cephalezomine. The key step entails the intramolecular Heck cyclization F→H.