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Synfacts 2008(1): 0057-0057  
DOI: 10.1055/s-2007-991477
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Cyclopropanation of Electron-Deficient Olefins

Contributor(s): Mark Lautens, Praew Thansandote
Y. Chen, J. V. Ruppel, X. P. Zhang*
University of South Florida, Tampa and University of Tennessee, Knoxville, USA
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

A highly efficient, general, and mild catalytic system for asymmetric cyclopropanation of electron-deficient olefins using a chiral Co(II)-porphyrin complex is presented. A variety of electron-withdrawing groups on the olefin are tolerated, even as part of di- or trisubstituted olefins.