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Synfacts 2008(1): 0079-0079
DOI: 10.1055/s-2007-991436
DOI: 10.1055/s-2007-991436
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Aminoborane-Mediated Ugi-Type Reaction with Secondary Amines
Y. Tanaka, T. Hasui, M. Suginome*
Kyoto University, Japan
Further Information
Publication History
Publication Date:
18 December 2007 (online)
Significance
This novel Ugi-type three-component reaction, which is mediated by aminoborane 1, allows the use of secondary amines in contrast to the original Ugi reaction. The reaction proceeds with tolerance of many functional groups due to its non-acidic conditions and provides an access to various α-amino acids.