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Synfacts 2007(12): 1235-1235  
DOI: 10.1055/s-2007-991309
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Leucascandrolide A

Contributor(s): Philip Kocienski
L. J. Van Orden, B. D. Patterson, S. D. Rychnovsky*
University of California, Irvine, USA
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

Leucascandolide A shows high cytotoxicity towards various cancer cell lines as well as antifungal activity. The Rychnovsky synthesis examplifies the power of the Mukaiyama aldol-Prins (MAP) reaction for the construction of cis-2,6-disubstituted tetrahydropyran rings.