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Synfacts 2007(11): 1133-1133  
DOI: 10.1055/s-2007-991291
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Regioselective Synthesis of Pyrazoles from β-Oxo Thioxoesters and α-Oxoketene O,N-Acetals

Contributor(s): Victor Snieckus, Wei Gan
M. E. F. Braibante, H. T. S. Braibante, L. Carvalho de Tavares, S. F. Rohte, C. C. Costa, A. F. Morel, C. Z. Stüker, R. A. Burrow
Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

A regioselective synthesis of pyrazoles under identical solid support and ultrasound conditions is reported. However, the regioselecti­vity is a function of β-oxo thioxoester A and α -oxo­ketene O,N-acetal B starting materials perhaps owing to higher electrophilicity of thioester and oxo­ketene acetal carbonyl, respectively. The scope of the reaction was not adequately investigated.