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Synfacts 2007(11): 1152-1152  
DOI: 10.1055/s-2007-991287
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Spin Trap Radical Detector

Contributor(s): Timothy M. Swager, Jeewoo Lim
S. T. Caldwell, C. Quin, R. Edge, R. C. Hartley*
University of Glasgow and University of Manchester, UK
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

It is believed that reactive oxygen species (ROS), such as hydroxyl radicals and peroxyl radicals, play a role in the process of aging and in diseases such as Parkinson’s and Alz­heimer’s diseases. The ability to detect such radicals selectively in an in vivo environment would provide a potent tool in studying the role of the oxy­gen-based radicals in such biological processes and would serve as a potential diagnostic tool. In this report, the authors describe a molecule which, coupled with electroparamagnetic resonance (EPR) spectroscopy, can achieve such feat.