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Synfacts 2007(11): 1165-1165  
DOI: 10.1055/s-2007-991261
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Fam-Ti-Catalyzed Enantioselective Alkynylation of Aldehydes

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
H. Koyuncu, Ö. Dogan*
Middle East Technical University, Ankara, Turkey
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

This paper reports the development of a nice ferrocenyl-based catalyst. The authors use this catalyst for the alkynylation of aromatic, hetero­aromatic, alkyl and α,β-unsaturated aldehydes with a variety of alkynyl zincs. Moderate to very high ee values are obtained for this reaction, indicating its utility. Low concentrations of reagents as well as short reaction times also make this an attractive protocol.