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Synfacts 2007(11): 1199-1199  
DOI: 10.1055/s-2007-991225
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Selective Iron-Catalyzed Biaryl Coupling: Suppression of Homocoupling

Contributor(s): Paul Knochel, Tobias Thaler
T. Hatakeyama, M. Nakamura*
Kyoto University, Japan
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The authors have found a useful method for selective iron-catalyzed biaryl coupling. Homocoupling is efficiently suppressed by applying a combination of FeF3 and SiPr×HCl as catalyst system. The fluoride anion hereby plays a crucial role, since replacing FeF3 with FeCl3 proceeds with predominance of the homocoupling reaction.