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Synfacts 2007(11): 1218-1218
DOI: 10.1055/s-2007-991221
DOI: 10.1055/s-2007-991221
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Suzuki Cross-Coupling Reaction with Chitosan-Supported Palladium(0) Catalyst in Water
S.-S. Yi, D.-H. Lee, E. Sin, Y.-S. Lee*
Seoul National University, Korea
Further Information
Publication History
Publication Date:
23 October 2007 (online)
Significance
The reaction of chitosan beads with Pd(OAc)2 gave chitosan-supported palladium(II). Then the palladium(II) in the chitosan beads was converted into palladium(0) (polymeric Pd 1) by treatment with hydrazine hydrate. The chitosan-palladium polymeric composite 1 was crosslinked by diglycidyl ether polyethylene glycol to yield catalyst 2. The Suzuki cross-coupling reaction of various aryl halides and aryl boronic acids was carried out with catalyst 2 in water under microwave-irradiation conditions to afford the corresponding biaryl compounds in 14-98% yield. The presence of tetrabutylammonium bromide accelerated the reaction.