Synfacts 2007(11): 1215-1215  
DOI: 10.1055/s-2007-991214
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Nano-Pd-Catalyzed α-Alkylation of Ketones with Alkanols

Contributor(s): Yasuhiro Uozumi, Hiroe Takenaka
Y. M. A. Yamada, Y. Uozumi*
Institute for Molecular Science, Okazaki, Japan
Further Information

Publication History

Publication Date:
23 October 2007 (online)

Significance

Ketones were alkylated with alcohols at their α-positions by use of a viologen polymer-supported nano-Pd catalyst. Linear viologen polymer 1 was ionically convoluted with palladate dianion to give polymeric palladate 2. Reduction of polymeric palladate 2 gave the viologen polymer-dispersion of nano-palladium particles (nano-Pd-V; 3). Methyl ketones 4 reacted with primary alkanols 5 in the presence of the nanopalladium catalyst 3 and an inorganic base to give the corresponding α-alkylated products in good to exellent yields.