Augmentation of Clozapine with Valproic Acid for Clozapine-Induced Obsessive-Compulsive Symptoms

The comorbidity of obsessive-compulsive symptoms (OCS) and schizophrenia has been documented by epidemiological investigations [2] [9] [12]. OCS is thought to markedly increase the risk of suicides in schizophrenia [11]. Within the multiple pathogenetic factors leading to OCS in schizophrenic patients, treatment with atypical antipsychotics such as clozapine has been discussed for a significant subgroup of these patients [6] [10]. Here, we report the improvement of clozapine-induced OCS after dose reduction to minimal sufficient levels facilitated by augmentation with valproic acid.

References

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