Congenital Brucellosis: A Rare Cause of Respiratory Distress in Neonates

ABSTRACT

Brucellosis represents a rare cause of neonatal infection. In this article we report a very unusual case of congenital infection due to Brucella melitensis in a term neonate presenting after birth with severe respiratory distress and radiological manifestations (lobar consolidation and diffuse interstitial infiltrations) compatible with pulmonary involvement. The neonate was successfully treated with trimethoprim-sulfamethoxazole, rifampicin, and gentamicin.

Brucella - neonate - respiratory distress

REFERENCES

• 1 Pappas G, Akritidis N, Bosilkovski M et al.. Brucellosis.  N Engl J Med. 2005;  352 2325-2336
• 2 Khan M Y, Mah M W, Memish Z A. Brucellosis in pregnant women.  Clin Infect Dis. 2001;  32 1172-1177
• 3 Chheda S, Lopez S M, Sanderson E P. Congenital brucellosis in a premature infant.  Pediatr Infect Dis J. 1997;  16 81-83
• 4 al-Eissa Y A, al-Mofada S M. Congenital brucellosis.  Pediatr Infect Dis J. 1992;  11 667-671
• 5 Labrune P, Jabir B, Magny J F et al.. Recurrent enterocolitis-like symptoms as a possible presenting manifestation of neonatal Brucella melitensis infection.  Acta Paediatr Scand. 1990;  79 707-709
• 6 Oran O, Karslioglu A, Secmeer G et al.. A premature infant with Brucella abortus infection.  Turk J Pediatr. 1983;  25 139-142
• 7 Giannacopoulos I, Eliopoulou M I, Ziambraras T et al.. Transplacentally transmitted congenital brucellosis due to Brucella abortus .  J Infect. 2002;  45 209-210
• 8 Singer R, Amitai Y, Geist M et al.. Neonatal brucellosis possibly transmitted during delivery.  Lancet. 1991;  338 127-128
• 9 Lubani M M, Dubin K I, Sharda D C et al.. Neonatal brucellosis.  Eur J Pediatr. 1988;  147 520-522
• 10 al-Kharfy T M. Neonatal brucellosis and blood transfusion: case report and review of the literature.  Ann Trop Paediatr. 2001;  21 349-352
• 11 Pappas G, Bosilkovski M, Akritidis N et al.. Brucellosis and the respiratory system.  Clin Infect Dis. 2003;  37 e95-e99
• 12 Lubani M M, Lulu A R, Araj G F et al.. Pulmonary brucellosis.  Q J Med. 1989;  71 319-324
• 13 Gattas N, Loberant N, Rimon D. Miliary and reticulo-nodular pulmonary brucellosis.  Harefuah. 1998;  135 357-359,407
• 14 Lopez A, Hitos F, Perez A et al.. Lung lesions in bovine fetuses aborted by Brucella abortus .  Can J Comp Med. 1984;  48 275-277
• 15 Shaalan M A, Memish Z A, Mahmoud S A et al.. Brucellosis in children: clinical observations in 115 cases.  Int J Infect Dis. 2002;  6 182-186
• 16 American Academy of Pediatrics . Brucellosis. In: Pickering LK Red Book: 2003 Report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, IL; American Academy of Pediatrics 2003: 222-224
• 17 Khuri-Bulos N A, Daoud A H, Azab S M. Treatment of childhood brucellosis: results of a prospective trial on 113 children.  Pediatr Infect Dis J. 1993;  12 377-383