Planta Med 2007; 73(11): 1214-1216
DOI: 10.1055/s-2007-981595
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Silyamandin, a New Flavonolignan Isolated from Milk Thistle Tinctures

Shawna L. MacKinnon1 , Mark Hodder1 , Cheryl Craft1 , Joanne Simmons-Boyce1
  • 1National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, Canada
Further Information

Publication History

Received: February 21, 2007 Revised: July 11, 2007

Accepted: July 11, 2007

Publication Date:
07 September 2007 (online)

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Abstract

Our investigations into the stability of tincture preparations of milk thistle fruit [Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2R,3R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic acid called silyamandin (1). Incubation of the tincture at 40 °C for 3 months resulted in an increase in the level of this compound, as observed in the LC/DAD silymarin profile.

References

Dr. S. L. MacKinnon

National Research Council Canada

Institute for Marine Biosciences

1411 Oxford Street

Halifax

NS

Canada B3H 4Z1

Phone: +1-902-426-6351

Fax: +1-902-426-9413

Email: shawna.mackinnon@nrc-cnrc.gc.ca