Planta Med 2007; 73(7): 696-698
DOI: 10.1055/s-2007-981541
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Two New Thiophenes from Echinops latifolius and their Phototoxic Activities

Yi Wang1 , Xian Li1 , Lin-Hao Li2 , Da-Li Meng1 , Zhan-Lin Li1 , Ning Li1
  • 1Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, P.R. China
  • 2School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P.R. China
Further Information

Publication History

Received: November 7, 2006 Revised: May 6, 2007

Accepted: May 8, 2007

Publication Date:
13 June 2007 (online)

Preview

Abstract

Two new thiophenes, 5-{4-[4-(5-pent-1,3-diynylthiophen-2-yl)-but-3-ynyloxy]-but-1-ynyl}-2,2′-bithiophene (1) and 5-(4-hydroxybut-1-one)-2,2′-bithiophene (2), together with two known thiophenes 5-(4-hydroxybut-1-ynyl)-2,2′-bithiophene (3) and 5-(3,4-dihydroxybut-1-ynyl)-2,2′-bithiophene (4), were isolated from the roots of Echinops latifolius Tausch. Their structures were elucidated based on the detailed NMR spectroscopic analysis and comparison with literature values. Compounds 1 and 2 showed significant inhibition activities against human cancer cell lines A375-S2 and HeLa with IC50 values from 3.1 to 13.5 μmol/L, depending on their exposure to long wavelength ultraviolet light.

References

Prof. Xian Li

Research Department of Natural Medicine

Shenyang Pharmaceutical University

Box 49

Shenyang 110016

People’s Republic of China

Phone: +86-24-2398-6475

Email: proflixian@163.com