ABSTRACT
In the present study, we performed sciatic nerve compression for 30, 45, and 60 minutes
by the Yasargil aneurysm clip and observed recovery on postoperative days 14, 28,
and 42. We observed that as compress time increases, functional recovery and morphological
regeneration of crushed sciatic nerve needs longer time. Additionally, we showed which
cells are durable in nerve regeneration after crush injury. Nerve regeneration or
recovery depends on trauma durations in which a longer recovery time is needed after
longtime pressure. Although Schwann cells are found to be resistant and this might
be for the cleanup of debris and remyelinization at mild injury, macrophage infiltration
is necessary for the cleanup of damaged fragments of cells and fibers. The result
indicates that a strong relationship exists between nerve damage and subsequent recovery.
This phenomenon may depend on crush severity that is associated with mechanic pressure
and inadequate logistic supports such as malnutrition and hypoxia. Additionally, we
found that the Yasargil aneurysm clip is an appropriate device to perform a standard
experimental severe crush injury model.
KEYWORDS
Yasargil-Phynox aneurysm clip - crush injury - sciatic nerve - axonal regeneration
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Dr. Levent Sarikcioglu
Department of Anatomy, Akdeniz University Faculty of Medicine
07070 Antalya, Turkey
