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Synfacts 2007(8): 0857-0857  
DOI: 10.1055/s-2007-968747
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Magnesiation of Electron-Rich Aryl Bromides and Cross-Coupling Reactions

Contributor(s): Paul Knochel, Tobias Thaler
S. Y. W. Lau*, G. Hughes, P. D. O’Shea, I. W. Davies
Merck Frosst Centre for Therapeutic Research, Kirkland, Canada and Merck Research Laboratories, Rahway, USA
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

The authors show that lithium tri­butylmagnesiate [(n-Bu)3MgLi] is a suitable reagent for the bromine-magnesium exchange with electron-rich aryl bromides. The respective lithium triarylmagnesiates form with low reaction times and can be efficiently subjected to Ni-catalyzed Kumada-Corriu cross-coupling reactions.