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Synfacts 2007(8): 0795-0795  
DOI: 10.1055/s-2007-968721
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of UCS 1025A

Contributor(s): Philip Kocienski, Indu Dager
R. M. de Figueiredo, R. Fröhlich, M. Christmann*
RWTH Aachen and Westfälische Wilhelms-Universität Münster, Germany
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

UCS 1025A is isolated from the fermentation broth of the Acremonium sp. KY 4917 fungus and possesses antiproliferative activity. The key step is a soft enolization-aldol condensation transforming maleimidobutyric acid A to the pyrrolizidine C.