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Synfacts 2007(7): 0718-0718  
DOI: 10.1055/s-2007-968667
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Directed Catalytic Asymmetric Olefin Metathesis

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
R. E. Giudici, A. H. Hoveyda*
Boston College, chestnut Hill, USA
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

Olefin metathesis is clearly one of the most powerful organic transformations to date. The E-olefin is predominantly formed in this ring-opening/cross-metathesis protocol. High ee values are obtained for a variety of substrates, generating quaternary carbons with high selectivity. Five mol% of the chiral ruthenium complex 1 are used with THF as solvent.