Synthesis of Khafrefungin

S.-i Shirokawa; M. Shinoyama; I. Ooi; S. Hosokawa; A. Nakazaki; S. Kobayashi

doi:10.1055/s-2007-968607

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Synfacts 2007(7): 0670-0670
DOI: 10.1055/s-2007-968607

Synthesis of Natural Products and Potential Drugs

Synthesis of Khafrefungin

Contributor(s): Philip Kocienski, Stewart Eccles
S-i. Shirokawa, M. Shinoyama, I. Ooi, S. Hosokawa, A. Nakazaki, S. Kobayashi*
Tokyo University of Science (RIKADAI), chiba, Japan

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Publication History

Publication Date:
22 June 2007 (online)

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Significance

Khafrefungin is an antifungal agent that inhibits inositol phosphorylceramide synthase. This synthesis utilizes a highly stereoselective vinylogous Mukaiyama aldol reaction.