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Synfacts 2007(7): 0668-0668  
DOI: 10.1055/s-2007-968602
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Nakadomarin A

Contributor(s): Philip Kocienski, Zofia Komsta
I. S. Young, M. A. Kerr*
The University of Western Ontario, London, Canada
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

(-)-Nakadomarin A was isolated from the marine sponge Amphimedon and belongs to the manzamine alkaloid family. The focal step of the synthesis is a homo-1,3-dipolar cyclo­addition of cyclopropane diester C and nitrone D.