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Synfacts 2007(7): 0675-0675
DOI: 10.1055/s-2007-968597
DOI: 10.1055/s-2007-968597
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Thiolactomycin
K. L. Dormann, R. Brückner*
Universität Freiburg, Germany
Further Information
Publication History
Publication Date:
22 June 2007 (online)
Significance
Thiolactomycin is a thiotetronic acid antibiotic produced by a Nocardia actinomycete. A synthesis of thiolactomycin and analogues is reported which features an anti-selective SN2′ reaction of a vinyl epoxide with a thiocarboxylate nucleophile.