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Synfacts 2007(6): 0612-0612  
DOI: 10.1055/s-2007-968554
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

First Rh(III)-Catalyzed Enantioselective Hydrosilylation of β-Keto Esters

Contributor(s): Mark Lautens, Yann Béthuel
Q. Xu, X. Gu, S. Liu, Q. Dou, M. Shi*
East China University of science and technology, Shanghai and Shanghai Institute of Organic Chemistry, P. R. of China
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Publikationsdatum:
22. Mai 2007 (online)

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Significance

In the present paper, the authors report on the synthesis of the biologically relevant β-hydroxy ester motif. It features an unprecedented enantioselective hydrosilylation of β-keto esters using NHC-Rh catalyst systems.