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Synfacts 2007(5): 0476-0476  
DOI: 10.1055/s-2007-968465
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Regioselective Cu(I)-Zeolite-Catalyzed Synthesis of Triazoles

Contributor(s): Victor Snieckus, Heiko Scharl
S. Chassaing, M. Kumarraja, A. S. S. Sido, P. Pale*, J. Sommer*
Université Louis Pasteur, Strasbourg, France
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

A highly regioselective heterogeneously catalyzed [3+2] cycloaddition of primary alkynes with azides to afford triazoles in good to excellent yields is reported. Five different synthesized Cu(I)-modified zeolites have been investigated. Only terminal alkynes and aryl and benzyl azides have been tested in this reaction.