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Synfacts 2007(5): 0456-0456  
DOI: 10.1055/s-2007-968390
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cytostatin

Contributor(s): Philip Kocienski, Fiona Black
B. G. Lawhorn, S. B. Boga, S. E. Wolkenberg, D. A. Colby, C.-M. Gauss, M. R. Swingle, L. Amable, R. E. Honkanen, D. L. Boger*
The Scripps Research Institute, La Jolla and University of South Alabama College of Medicine, Mobile, USA
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

A convergent synthesis of cytostatin and its C10 and C11 stereoisomers is reported which confirms the relative and absolute stereo­chemistry of this cytotoxic natural product. Several cytostatin analogues are also synthesized for ­biological evaluation.