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Synfacts 2007(4): 0344-0344  
DOI: 10.1055/s-2007-968285
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Kinamycin C

Contributor(s): Philip Kocienski, Fiona Black
X. Lei, J. A. Porco, Jr.*
Boston University, USA
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Publication History

Publication Date:
23 March 2007 (online)

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Significance

Kinamycin C, isolated from Streptomyces murayamansis, exhibits antibacterial and antibiotic properties and contains an unusual diazo­benzofluorene moiety. Two of the four stereo­centers are installed using a tartrate-mediated nucleophilic asymmetric epoxidation reaction.