Synthesis of (+)-Abscisic Acid

T. R. Smith; A. J. Clark; G. J. Clarkson; P. C. Taylor; A. Marsh

doi:10.1055/s-2007-968280

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Synfacts 2007(4): 0353-0353
DOI: 10.1055/s-2007-968280

Synthesis of Natural Products and Potential Drugs

Synthesis of (+)-Abscisic Acid

Contributor(s): Philip Kocienski, Indu Dager
T. R. Smith, A. J. Clark, G. J. Clarkson, P. C. Taylor, A. Marsh*
University of Warwick, UK

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Publication History

Publication Date:
23 March 2007 (online)

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Significance

The phytohormone abscisic acid plays a crucial role in transpiration, seed germination, embryo maturation and stress responses in plants. An efficient synthesis of both enantiomers of abscisic acid (6 steps, 30% overall yield) starting from commercially available 4-oxoisophrone is reported.