In Vivo Antimalarial Activity of Isosungucine, an Indolomonoterpenic Alkaloid from Strychnos icaja

Abstract

Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.

References

• 1 Greenwood B M, Bojang K, Whitty C JM, Targett G AT. Malaria.  Lancet. 2005;  365 1487-98.
• 2 Hyde J E. Drug-resistant malaria.  Trends Parasitol. 2005;  21 494-8.
• 3 Neuwinger H D. Alkaloids in arrow poisons. In: Roberts MC, Wink M, editors Alkaloids: biochemistry, ecology and medicinal applications. New York; Plenum Press 1998: 45-84.
• 4 Neuwinger H D. African ethnobotany: Poisons and drugs, chemistry, pharmacology, toxicology. London; Chapman & Hall 1996: 569-78.
• 5 Iwu M. Handbook of African medicinal plants. Boca Raton; CRC Press 1993: 244-5.
• 6 Wright C W, Bray D H, O'Neill M J, Warhurst D C, Phillipson J D, Quetin-Leclercq J. et al . Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis .  Planta Med. 1991;  57 337-40.
• 7 Wright C W, Allen D, Cai Y, Chen Z P, Phillipson J D, Kirby G C. et al . Selective antiprotozoal activity of some Strychnos alkaloids.  Phytother Res. 1994;  8 149-52.
• 8 Frederich M, Hayette M P, Tits M, De Mol P, Angenot L. In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum .  Antimicrob Agents Chemother. 1999;  43 2328-31.
• 9 Frederich M, Tits M, Goffin E, Philippe G, Grellier P, De Mol P. et al . In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis .  Planta Med. 2004;  70 520-5.
• 10 Frederich M, De Pauw M, Prosperi C, Tits M, Brandt V, Penelle J. et al . Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja .  J Nat Prod. 2001;  64 12-6.
• 11 Philippe G, Nguyen L, Angenot L, Frederich M, Moonen G, Tits M. et al . Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor.  Eur J Pharmacol. 2006;  530 15-22.
• 12 Frederich M, Depauw-Gillet M C, Llabres G, Tits M, Hayette M P, Brandt V. et al . New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots.  Planta Med. 2000;  66 262-9.
• 13 Peters W, Robinson B L. The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium .  Ann Trop Med Hyg. 1991;  85 5-10.
• 14 Pink R, Hudson A, Mouries M A, Bendig M. Opportunities and challenges in antiparasitic drug discovery.  Nat Rev Drug Discov. 2005;  4 727-40.
• 15 Fidock D A, Rosenthal P J, Croft S L, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening.  Nat Rev Drug Discov. 2004;  3 509-20.
• 16 Frederich M, Jacquier M J, Thepenier P, De Mol P, Tits M, Philippe G. et al . Antiplasmodial activity of alkaloids from various Strychnos species.  J Nat Prod. 2002;  65 1381-6.