Endoscopy 2007; 39: E240-E241
DOI: 10.1055/s-2007-966793
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Implantation of an esophageal squamous cell carcinoma at the site of a percutaneous endoscopic gastrostomy

K.  Volkmer1 , T.  Meyer1 , M.  Sailer2 , M.  Fein1
  • 1Department of Surgery, University Hospital of Wuerzburg, Julius-Maximilians-University Wuerzburg, Germany
  • 2Bethesda Hospital, Hamburg-Bergedorf, Germany
Further Information

M. Fein, MD

Department of Surgery

Zentrum Operative Medizin (ZOM)

Oberduerrbacher Strasse 6

D - 97080 Wuerzburg

Germany

Fax: +49-931-201-31049

Email: Fein_M@chirurgie.uni-wuerzburg.de

Publication History

Publication Date:
24 October 2007 (online)

Table of Contents

A 54-year-old man presented with a stenosing, moderately differentiated squamous cell carcinoma (SCC) of the proximal esophagus. Tumor stage was cT3-4N1M0. The patient underwent radiochemotherapy with curative intent. A percutaneous endoscopic gastrostomy (PEG) was placed using the standard pull-through method.

After 5 months the patient noticed a skin alteration at the site of the PEG, which was regarded as granulation tissue ([Fig. 1]). In a routine gastroscopy 2 months later, an ulcer at the gastric site of the PEG was found ([Fig. 2]), and initially diagnosed as adenocarcinoma. Computed tomography demonstrated a tumor mass along the PEG-tube ([Fig. 3]). Additionally, a suspicious hypodense hepatic lesion was detected. Complete local esophageal tumor control was documented. At laparotomy, a frozen section of the liver lesion showed a poorly differentiated SCC. Therefore, palliative subtotal gastrectomy with en bloc resection of the abdominal wall was carried out ([Fig. 4]).

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Fig. 1 Macroscopic aspect showing the skin alteration at the site of the PEG, which was regarded as granulation tissue.

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Fig. 2 Gastroscopic view of the tumor at the PEG site.

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Fig. 3 Metastatic tumor implantation at the site of the PEG; the tumor mass extends from the gastric lumen to the skin.

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Fig. 4 Esophageal squamous cell carcinoma with distinctive lymphangiosis and hemangiosis carcinomatosa (H & E staining).

Since the first description of PEG in 1980 [1], it has become a valuable method for nutritional support. The implantation of oropharyngeal or esophageal cancer at PEG stoma sites is a rare complication with an unknown incidence [2]. The average period of time from tube placement to metastatic spread is reported to be approximately 9 months (range 3 - 18 months) [3]. Length of survival following this complication is rarely reported, and varies between 2 and 28 months [4]. The mechanism of tumor spread to the PEG site is controversial. Hematogenous or lymphatic spread to a susceptible site, as well as - more likely - direct mechanical implantation at the time of the PEG placement are proposed [3] [4] [5]. To avoid mechanical tumor implantation, the contact of the PEG tube with the tumor should be minimized. In patients with bulky, stenosing tumors this can be achieved by using a sheath or overtube. Alternatively, radiologic or operative placements can be carried out.

Endoscopy_UCTN_Code_CPL_1AH_2AI

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References

M. Fein, MD

Department of Surgery

Zentrum Operative Medizin (ZOM)

Oberduerrbacher Strasse 6

D - 97080 Wuerzburg

Germany

Fax: +49-931-201-31049

Email: Fein_M@chirurgie.uni-wuerzburg.de

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References

M. Fein, MD

Department of Surgery

Zentrum Operative Medizin (ZOM)

Oberduerrbacher Strasse 6

D - 97080 Wuerzburg

Germany

Fax: +49-931-201-31049

Email: Fein_M@chirurgie.uni-wuerzburg.de

Zoom Image

Fig. 1 Macroscopic aspect showing the skin alteration at the site of the PEG, which was regarded as granulation tissue.

Zoom Image

Fig. 2 Gastroscopic view of the tumor at the PEG site.

Zoom Image

Fig. 3 Metastatic tumor implantation at the site of the PEG; the tumor mass extends from the gastric lumen to the skin.

Zoom Image

Fig. 4 Esophageal squamous cell carcinoma with distinctive lymphangiosis and hemangiosis carcinomatosa (H & E staining).