Tissue Engineering and Tissue Repair in Immunocompetent Animals: Tissue Construction and Repair

Abstract

Tissue engineering can regenerate autologous tissue using a biodegradable scaffold and in vitro expanded cells derived from small biopsy samples, and thus may have great potential for tissue repair and reconstruction in plastic and reconstructive surgery. As an important step towards a clinical application, research work in large animals is essential. This article presents our experience of tissue engineering and repair in large animals in the areas of bone, cartilage and tendon.

Zusammenfassung

Das Tissue Engineering bietet durch die Anwendung biologisch abbaubarer Trägerstrukturen, die mit in vitro expandierten und durch eine kleine Biopsie gewonnenen autologen Zellen besiedelt werden, eine vielversprechende Perspektive für die Regeneration von autologem Gewebe und die Wiederherstellung bei Gewebedefekten in der Plastischen Chirurgie. Ein wichtiger Schritt auf dem Weg zur klinischen Anwendung sind experimentelle Untersuchungen in größeren Versuchstieren wie dem Schaf. Die vorliegende Arbeit fasst unsere experimentellen Erfahrung mit dem Tissue Engineering und der Geweberekonstruktion von Knochen, Knorpel und Sehnen im Tierversuch zusammen.

tissue engineering - bone - cartilage - tendon

Gewebezüchtung - Knochen - Knorpel - Sehne

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