Tissue Engineering and Tissue Repair in Immunocompetent Animals: Tissue Construction and Repair

Abstract

Tissue engineering can regenerate autologous tissue using a biodegradable scaffold and in vitro expanded cells derived from small biopsy samples, and thus may have great potential for tissue repair and reconstruction in plastic and reconstructive surgery. As an important step towards a clinical application, research work in large animals is essential. This article presents our experience of tissue engineering and repair in large animals in the areas of bone, cartilage and tendon.

Zusammenfassung

Das Tissue Engineering bietet durch die Anwendung biologisch abbaubarer Trägerstrukturen, die mit in vitro expandierten und durch eine kleine Biopsie gewonnenen autologen Zellen besiedelt werden, eine vielversprechende Perspektive für die Regeneration von autologem Gewebe und die Wiederherstellung bei Gewebedefekten in der Plastischen Chirurgie. Ein wichtiger Schritt auf dem Weg zur klinischen Anwendung sind experimentelle Untersuchungen in größeren Versuchstieren wie dem Schaf. Die vorliegende Arbeit fasst unsere experimentellen Erfahrung mit dem Tissue Engineering und der Geweberekonstruktion von Knochen, Knorpel und Sehnen im Tierversuch zusammen.

Key words

tissue engineering - bone - cartilage - tendon

Schlüsselwörter

Gewebezüchtung - Knochen - Knorpel - Sehne

References

• 1 Cao D, Liu W, Wei X, Xu F, Cui L, Cao Y. In vitro tendon engineering with avian tenocytes and polyglycolic acids: a preliminary report.  Tissue Eng. 2006;  12 1369-1377
• 2 Cao Y, Liu Y, Liu W, Shan Q, Buonocore S D, Cui L. Bridging tendon defects using autologous tenocyte engineered tendon in a hen model.  Plast Reconstr Surg. 2002;  110 1280-1289
• 3 Cao Y, Vacanti J P, Paige K T, Upton J, Vacanti C A. Transplantation of chondrocytes utilizing a polymer cell construct to produce tissue engineered cartilage in the shape of a human ear.  Plast Reconstr Surg. 1997;  100 297-304
• 4 Evans J F, Niu Q T, Canas J A, Shen C L, Aloia J F, Yeh J K. ACTH enhances chondrogenesis in multipotential progenitor cells and matrix production in chondrocytes.  Bone. 2004;  35 96-107
• 5 Fukumoto T, Sperling J W, Sanyal A, Fitzsimmons J S, Reinholz G G, Conover C A, O'Driscoll S W. Combined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitro.  Osteoarthritis Cartilage. 2003;  11 55-64
• 6 Langer R, Vacanti J P. Tissue engineering.  Science. 1993;  260 920-926
• 7 Liu W, Chen B, Deng D, Xu F, Cui L, Cao Y. Repair of tendon defect with dermal fibroblast engineered tendon in a porcine model.  Tissue Eng. 2006;  12 775-788
• 8 Liu W, Cui L, Cao Y. A closer view of tissue engineering in China: the experience of tissue construction in immunocompetent animals.  Tissue Eng. 2003;  9 S17-30
• 9 Liu Y, Chen F, Liu W, Cui L, Shang Q, Xia W, Wang J, Cui Y, Yang G, Liu D, Wu J, Xu R, Buonocore S D, Cao Y. Repairing large porcine full-thickness defects of articular cartilage using autologous chondrocyte-engineered cartilage.  Tissue Eng. 2002;  8 709-721
• 10 Mastrogiacomo M, Cancedda R, Quarto R. Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells.  Osteoarthritis Cartilage. 2001;  9 S36-S40
• 11 Pittenger M F, Mackay A M, Beck S C, Jaiswal R K, Douglas R, Mosca J D, Moorman M A, Simonetti D W, Craig S, Marshak D R. Multilineage potential of adult human mesenchymal stem cells.  Science. 1999;  284 143-147
• 12 Shang Q, Wang Z, Liu W, Shi Y, Cui L, Cao Y. Tissue-engineered bone repair of sheep cranial defects with autologous bone marrow stromal cells.  J Craniofac Surg. 2001;  12 586-593
• 13 Vacanti C A, Kim W, Upton J, Vacanti M P, Mooney D, Schloo B, Vacanti J P. Tissue-engineered growth of bone and cartilage.  Transplant Proc. 1993;  25 1019-1021
• 14 Wakitani S, Imoto K, Yamamoto T, Saito M, Murata N, Yoneda M. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees.  Osteoarthritis Cartilage. 2002;  10 199-206
• 15 Weng Y, Wang M, Liu W, Hu X, Chai G, Yan Q, Zhu L, Cui L, Cao Y. Repair of experimental alveolar bone defects by tissue engineered bone.  Tissue Eng. 2006;  12 1503-1513
• 16 Williams C G, Kim T K, Taboas A, Malik A, Manson P, Elisseeff J. In vitro chondrogenesis of bone marrow-derived mesenchymal stem cells in a photopolymerizing hydrogel.  Tissue Eng. 2003;  9 679-688
• 17 Winter A, Breit S, Parsch D, Benz K, Steck E, Hauner H, Weber R M, Ewerbeck V, Richter W. Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.  Arthritis Rheum. 2003;  48 418-429
• 18 Yuan J, Cui L, Zhang W J, Liu W, Cao Y. Repair of canine mandibular bone defects with bone marrow stromal cells and porous beta-tricalcium phosphate.  Biomaterials. 2007;  28 1005-1013
• 19 Zhou G, Liu W, Cui L, Wang X, Liu T, Cao Y. Repair of porcine articular osteochondral defects in non-weightbearing areas with autologous bone marrow stromal cells.  Tissue Eng. 2006;  12 3209-3221
• 20 Zhu L, Liu W, Cui L, Cao Y. Tissue-engineered bone repair of goat-femur defects with osteogenically induced bone marrow stromal cells.  Tissue Eng. 2006;  12 1369-1377