Einfluss eines frühen sensomotorischen Trainings auf die Erholung neuromotorischer Funktion nach experimentellem Schädel-Hirn-Trauma

Zusammenfassung

In der hier vorgestellten Studie wird der Einfluss einer frühen sensomotorischen Förderung (Rehabilitationsmodell) nach standardisiertemtierexperimentellen Schädel-Hirn-Trauma (Fluid-Percussion-Modell) auf neuromotorische Fähigkeiten untersucht. Die Untersuchungen wurden an männlichen erwachsenen Sprague-Dawley(SD)-Ratten durchgeführt. 24 Stunden nach Trauma wurden die Tiere randomisiert in zwei Testgruppen (Standard housing/Rehabilitationsmodell) eingeteilt wo sie bis zum Ende der Beobachtungszeiten (15 und 30 Tage) gehalten wurden. Die Baseline für die neuromotorische Testung (Testbatterie Neuroscore) wurde 24 Stunden vor Trauma erhoben, die Überprüfung der motorischen Erholung 24 Stunden, 7, 15 und 30 Tage nach Trauma vorgenommen. Die Ergebnis-se zeigen, dass die Rehabilitationsmodellgruppe im Vergleich zu der Standard-housing-Gruppe sowohl 15 als auch 30 Tage nach Trauma signifikant besser abschneidet (p<0,05).

Abstract

The study was designed to determine the influence of exposure to early sensomotorical training as a model of the early rehabilitative treatment after traumatic brain injury for the recovery of neuromotor functions. Male Sprague-Dawley rats were subjected to lateral fluid percussion brain injury. After trauma, one group of the animals were placed under conditions of standard housing, and the second portion of rats underwent an early sensomotorical training (rehabilitation model). Assessment of neuromotor deficits with a standardized composite neuroscore test revealed an almost identical pattern of neurological impairment in all animals subjected to LFP 24 h post-lesion. 15 days post-lesion as well as 30 days post lesion, the rehabilitation model rats performed significantly better than the standard housing rats (p<0,05), indicating a better recovery of neuromotorical functions.

Schlüsselwörter

sensomotorisches Training - Rehabilitation - Schädel-Hirn-Trauma - Motorik

Key words

sensomotorical training - rehabilitation - brain injury - neuromotor functions

Literatur

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1 Hinweis
M. Lippert-Grüner und M. Mägele beteiligten sich an der Herstellung der Arbeit gleichwertig und teilen sich die Erstautorschaft

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