ABSTRACT
Objective: Surgery is a cornerstone of treatment for a wide variety of neoplastic,
congenital, traumatic, and inflammatory lesions involving the midline anterior skull
base and may result in a significant anterior skull base defect requiring reconstruction.
This study is a retrospective analysis of the reconstruction techniques and complications
seen in a series of 58 consecutive patients with midline anterior skull base pathology
treated with craniotomy or a craniofacial approach. The complication rates in this
series are compared with other retrospective series and specific techniques that may
reduce complications are then discussed. Design: This is a retrospective analysis
of 58 consecutive patients who had surgery for a midline anterior skull base lesion
between January 1994 and July 2003. Data were collected regarding pathology, surgical
approach, reconstruction technique, and complications. Results: Twenty-nine patients
underwent surgery for a meningioma (50%). The remainder had frontoethmoidal cancer,
mucoceles/invasive nasal polyps, encephalocele, esthesioneuroblastoma, anterior falx
dermoid cyst with a nasal sinus tract, or invasive pituitary adenoma. In most patients,
a low and narrow two-piece biorbitofrontal craniotomy was used. When possible, the
dura was repaired before entering the nasal cavity. Thirteen patients experienced
a complication (22%). There was one case of postoperative cerebrospinal fluid (CSF)
leak (2%), one case of meningitis (2%), two cases of bone flap infection (3%), and
two cases of symptomatic pneumocephalus (3%). There were no deaths, no reoperations
for CSF leak, and no patient had a new permanent neurologic deficit other than anosmia.
Conclusions: Transcranial approaches for midline anterior skull base lesions can be
performed safely with a low incidence of postoperative CSF leak, meningitis, bone
flap infection, and symptomatic pneumocephalus. Our results, particularly with regard
to CSF leakage, compare favorably with other retrospective series.
KEYWORDS
Anterior skull base - cerebrospinal fluid leak - complications - craniofacial approach
- meningioma - skull base surgery
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James T KryzanskiM.D.
Department of Neurosurgery, Tufts New England Medical Center
750 Washington Street, Boston, MA 02111
Email: jkryzanski@tufts-nemc.org
