Semin Respir Crit Care Med 2006; 27(6): 613-622
DOI: 10.1055/s-2006-957333
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Histopathology of Pulmonary Fibrotic Disorders

Chi K. Lai1 , W. Dean Wallace1 , Michael C. Fishbein1
  • 1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California
Further Information

Publication History

Publication Date:
29 December 2006 (online)

ABSTRACT

Interstitial lung diseases encompass a broad spectrum of disorders that vary greatly in their clinical presentation, natural history, pathology, pathogenesis, prognosis, and treatment. Their correct classification requires integration of clinical, radiological, and pathological findings. Although these disorders may be well defined, interpretation of lung biopsy findings is often difficult, with surprisingly significant interobserver variability. This article reviews the histopathology of the major interstitial lung diseases, including the idiopathic interstitial pneumonias and pulmonary fibrotic disorders associated with collagen vascular diseases and smoking. In addition, the differential diagnosis of each of these disorders is discussed.

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Michael C FishbeinM.D. 

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA

10833 Le Conte Ave., CHS 13-145H, Los Angeles, CA 90095-1732

Email: mfishbein@mednet.ucla.edu

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